Heat shock transcription factors regulate heat induced cell death in a rat histiocytoma

@article{Prasad2007HeatST,
  title={Heat shock transcription factors regulate heat induced cell death in a rat histiocytoma},
  author={K V Prasad and Aftab Taiyab and D. Shanmukhi Jyothi and Usha K. Srinivas and Amere Subbarao Sreedhar},
  journal={Journal of Biosciences},
  year={2007},
  volume={32},
  pages={585-593}
}
Heat shock response is associated with the synthesis of heat shock proteins (Hsps) which is strictly regulated by different members of heat shock transcription factors (HSFs). We previously reported that a rat histiocytoma, BC-8 failed to synthesize Hsps when subjected to typical heat shock conditions (42°C, 60 min). The lack of Hsp synthesis in these cells was due to a failure in HSF1 DNA binding activity. In the present study we report that BC-8 tumor cells when subjected to heat shock at… 
High basal heat-shock protein expression in bats confers resistance to cellular heat/oxidative stress
TLDR
Bat cells survive prolonged heat treatment, along with other stress stimuli, in a HSP-dependent manner, whereas other mammalian cells succumbed, suggesting HSP expression in bats could be an important adaption to intrinsic metabolic stresses like flight and therefore an important model to study stress resilience and longevity in general.
Heat Shock Proteins in the Cancer Immunity: Comprehensive Review on Potential Chemotherapeutic Interventions
TLDR
A comprehensive cross-talk between Hsps and tumor immunity is provided and how Hsp-dependent and Hs-independent chemotherapeutic strategies can be used to target tumors both in vitro as well as in vivo is reviewed.
p27 Suppresses Arsenite-induced Hsp27/Hsp70 Expression through Inhibiting JNK2/c-Jun- and HSF-1-dependent Pathways*
TLDR
It is demonstrated that p27 suppresses Hsp27 and Hsp70 expression at the transcriptional level specifically through JNK2/c-Jun- and HSF-1-dependent pathways upon arsenite exposure, which provides additional important molecular mechanisms for the tumor-suppressive function of p27.
A benzophenanthridine alkaloid, chelerythrine induces apoptosis in vitro in a Dalton's lymphoma.
TLDR
It was confirmed by fluorescence microscopy, TEM analysis, and DNA fragmentation assay that 10 μg/mL of chelerythrine is capable of inducing apoptosis DL cells in vitro and therefore, it could be useful in combating tumor growth and progression.
Host autophagic degradation and associated symbiont loss in response to heat stress in the symbiotic anemone, Aiptasia pallida
TLDR
This study provides the first ultrastructural evidence of host autophagic degradation during thermal stress in a cnidarian system and supports earlier suggestions that autophagy is an active cellular mechanism during early stages of bleaching.
Genome-wide identification and functional prediction of long non-coding RNAs in Sprague-Dawley rats during heat stress
TLDR
This study is the first to provide a detailed characterization and functional analysis of expression levels of lncRNAs in liver and adrenal glands of heat-stressed rats, which provides basis for further studies on the biological functions of lNCRNAs under heat stress in rats and other mammalian species.
...
...

References

SHOWING 1-10 OF 49 REFERENCES
Roles of the heat shock transcription factors in regulation of the heat shock response and beyond
TLDR
The heat shock response, characterized by increased expression of heat shock proteins (Hsps), is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress, thereby providing a finely tuned balance between survival and death.
Heat Shock Response and Protein Degradation: Regulation of HSF2 by the Ubiquitin-Proteasome Pathway
TLDR
The downstream effect of HSF2 activation by proteasome inhibitors is the induction of the same set of heat shock genes that are induced during heat shock by HSF1, thus revealing that HSF 2 affords the cell with a novel heat shock gene-regulatory mechanism to respond to changes in the protein-degradative machinery.
Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells
TLDR
It is reported here that hemin activates the DNA-binding activity of HSF2, whereas heat shock induces predominantly theDNA- binding activity of a distinct factor, HSF1, which constitutes the first example ofHSF2 activation in vivo.
Stress-Specific Activation and Repression of Heat Shock Factors 1 and 2
TLDR
It is shown, using a novel DNA binding and detection assay, that HSF1 and HSF2 are coactivated to different levels in response to a range of conditions that cause cell stress and suggests a role for heat shock proteins in the positive regulation of HSF 2.
Activation of Fas inhibits heat‐induced activation of HSF1 and up‐regulation of hsp70
  • G. Schett, C. Steiner, G. Steiner
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1999
TLDR
It is concluded that inhibition of HSF1/hsp70 stress response during Fas‐mediated apoptosis and vice versa may facilitate a cell to pass a previously chosen pathway, stress resistance or apoptosis, without the influence of inhibitory signals.
Heat shock transcription factors: structure and regulation.
  • C. Wu
  • Biology
    Annual review of cell and developmental biology
  • 1995
TLDR
Analysis of HSF cDNA clones from many species has defined structural and regulatory regions responsible for the inducible activities of the conserved heat shock transcription factor.
Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.
TLDR
The protective role of HSPs is a measure of their capacity to assist in the repair of protein damage, through their chaperoning effects on proteins, protect cells from many forms of stress-induced cell damage and could influence the course of disease.
...
...