Heat shock response modulators as therapeutic tools for diseases of protein conformation.

@article{Westerheide2005HeatSR,
  title={Heat shock response modulators as therapeutic tools for diseases of protein conformation.},
  author={Sandy D Westerheide and Richard I. Morimoto},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 39},
  pages={33097-100}
}
The disruption of protein folding quality control results in the accumulation of a non-native protein species that can form oligomers, aggregates, and inclusions indicative of neurodegenerative disease. Likewise for over 100 other human diseases of protein confirmation, a common feature may be the formation of off-pathway folding intermediates that are unstable, self-associate, and with time lead to a chronic imbalance in protein homeostasis with deleterious consequences on cellular function… CONTINUE READING
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MINIREVIEW: Heat Shock Response and Disease 33100 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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