Heat-shock response is associated with decreased production of interleukin-6 in murine aortic vascular smooth muscle cells

@article{Kim2004HeatshockRI,
  title={Heat-shock response is associated with decreased production of interleukin-6 in murine aortic vascular smooth muscle cells},
  author={Inkyeom Kim and Heung-Mook Shin and Woonyi Baek},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={371},
  pages={27-33}
}
Heat shock has been known to change cellular responses to noxious stimuli by inducing heat-shock proteins (Hsps). We hypothesized that a heat-shock response modulates cytokine production in murine aortic vascular smooth muscle cells (VSMCs). VSMCs were exposed to 44°C for 15–60 min, and subjected to interleukin-1β (IL-1β) or tumor necrosis factor α (TNFα), which induced interleukin-6 (IL-6) production. Expression of Hsps was examined with immunoblots, immunocytochemistry, or enzyme-linked… CONTINUE READING