Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications

@inproceedings{Ciocca2005HeatSP,
  title={Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications},
  author={D. Ciocca and S. Calderwood},
  booktitle={Cell stress \& chaperones},
  year={2005}
}
Abstract Heat shock proteins (Hsps) are overexpressed in a wide range of human cancers and are implicated in tumor cell proliferation, differentiation, invasion, metastasis, death, and recognition by the immune system. We review the current status of the role of Hsp expression in cancer with special emphasis on the clinical setting. Although Hsp levels are not informative at the diagnostic level, they are useful biomarkers for carcinogenesis in some tissues and signal the degree of… Expand
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TLDR
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TLDR
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Title Expression levels of heat shock protein 20 decrease in parallel with tumor progression in patients with hepatocellular carcinoma
Heat shock protein (HSP) 20, a low-molecularweight HSP, is constitutively expressed in various tissues, such as smooth muscle, skeletal muscle, and liver. However, the characteristics and function ofExpand
Clinical, prognostic, and therapeutic significance of heat shock protein 27 in bladder cancer
TLDR
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Implications of Heat Shock Proteins in Carcinogenesis and Cancer Progression
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Heat Shock Proteins and Ovarian Cancer: Important Roles and Therapeutic Opportunities
TLDR
Light is shed on the diverse roles of HSPs as well as related chaperone proteins like CLU in the pathogenesis of ovarian cancer and elucidate their potential as effective drug targets. Expand
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References

SHOWING 1-10 OF 258 REFERENCES
Prognostic significance of heat shock protein 27 (HSP27) in patients with oral squamous cell carcinoma.
TLDR
It is suggested that the expression of HSP27 is frequently promoted in patients with Oral squamous cell carcinoma and should be considered an independent prognostic factor of oral squamouscell carcinoma patients. Expand
Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications.
TLDR
Investigating whether elevated hsp70 expression may be an indicator of biological stress experienced by a breast cancer and may, therefore, predict disease outcome found it to be useful in identifying patients at high risk for disease recurrence and thus may affect decisions regarding treatment after surgery. Expand
Hsp-27 has no diagnostic or prognostic significance in prostate or bladder cancers.
TLDR
It is concluded that hsp-27 expression has neither diagnostic nor prognostic significance and will not serve as a predictive biologic marker with these important genitourinary cancers. Expand
Prognostic significance of heat shock proteins HSP70 and HSP90 in endometrial carcinomas.
TLDR
Analysis of the survival of 44 endometrial carcinoma patients treated in the authors' hospital with reference to the immunohistochemical expressions of HSP70 and HSP90 found each have different prognostic significance in endometrian carcinoma and may be useful for prediction of patient survival. Expand
Significance of heat shock protein-27 expression in patients with renal cell carcinoma.
TLDR
The data suggest that HSP-27 expression is not a powerful and statistically significant prognostic indicator for disease-free survival for patients with RCC. Expand
Expression of the heat shock protein HSP27 in human ovarian cancer.
  • S. Langdon, G. Rabiasz, +4 authors W. Miller
  • Biology, Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 1995
TLDR
Analysis of ovarian cancer cell lines in vitro and in vivo indicated that the HSP27 content was higher in cell lines that were estrogen receptor rich and whose growth was modulated by estrogen as compared with those that were not. Expand
Heat shock proteins and cell proliferation in human breast cancer biopsy samples.
TLDR
It is demonstrated that in a significant percentage of clinical breast cancers hsp27 overexpression is inversely correlated with cell proliferation, while hsp70 is clearly associated with the mitotic spindle and cell proliferation. Expand
[Heat shock proteins and malignancies of the female genital tract].
TLDR
Since Hsp may affect the growth of the tumor and its response to chemotherapy, it is speculated that using drugs that inhibit Hsp in combination with conventional chemotherapy may contribute to the improvement of the treatment results. Expand
Serological detection of heat shock protein hsp27 in normal and breast cancer patients.
TLDR
Serological determination of this biomarker is unlikely to be of utility in the detection and follow-up of breast cancer patients because autoantibodies to hsp27 may be found in women with primary breast cancer. Expand
Heat shock protein expression independently predicts clinical outcome in prostate cancer.
TLDR
It is suggested that hsp27 expression provides novel diagnostic and prognostic information on individual patient survival which, if obtained at the time of primary diagnosis, would assist in determining tumor-specific management strategies. Expand
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