Heat shock proteins as markers of neural injury.

  title={Heat shock proteins as markers of neural injury.},
  author={M Fernanda Gonz{\'a}lez and Kenji Shiraishi and K Hisanaga and Stephen M. Sagar and M Mandabach and Frank R. Sharp},
  journal={Brain research. Molecular brain research},
  volume={6 1},
Systemic or intracerebral injections of kainic acid induced immunoreactivity for the 72 kDa heat shock protein (HSP72) in individual neurons of the rat brain in patterns matching the known histopathology of the particular injury. HSP72 immunostaining was also induced in and around areas of infarction following experimental strokes. These results suggest that HSP72 immunocytochemistry may be used as a marker of cellular injury in the mammalian brain.