Heat shock proteins and superantigenic properties of bacteria from the gastrointestinal tract of patients with Kawasaki disease.

@article{Nagata2009HeatSP,
  title={Heat shock proteins and superantigenic properties of bacteria from the gastrointestinal tract of patients with Kawasaki disease.},
  author={Satoru Nagata and Yuichiro Yamashiro and Yoshikazu Ohtsuka and Toshiaki Shimizu and Yumiko Sakurai and Shigeki Misawa and Teruyo Ito},
  journal={Immunology},
  year={2009},
  volume={128 4},
  pages={511-20}
}
We previously suggested that gut bacteria may be involved in the onset of Kawasaki disease (KD). In this study, we evaluated the production of heat shock proteins (hsps) and superantigens (sAgs) by microorganisms isolated from the jejunal mucosa of 19 children with KD in the acute phase and from 15 age-matched control children. We identified 13 strains of Gram-negative microbes from patients with KD; these microbes produced large amounts of hsp60 and induced pro-inflammatory cytokine production… CONTINUE READING
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