Heat shock proteins and p53 play a critical role in K+ channel-mediated tumor cell proliferation and apoptosis

@article{Han2007HeatSP,
  title={Heat shock proteins and p53 play a critical role in K+ channel-mediated tumor cell proliferation and apoptosis},
  author={Xiaobing Han and Fang Wang and Weixing Yao and Hui Jun Xing and Danhui Weng and Xiaohong Song and Gang Chen and Ling Xi and Tao Zhu and Jianfeng Zhou and Gang Xu and Shixuan Wang and Li Meng and C Iadecola and Gang Sam Wang and Ding Ma},
  journal={Apoptosis},
  year={2007},
  volume={12},
  pages={1837-1846}
}
Plasma membrane potassium (K+) channels are required for tumor cell proliferation and apoptosis. However, the signal transduction mechanisms underlying K+ channel-dependent tumor cell proliferation or apoptosis remains elusive. Using HeLa and A2780 cells as study models, we tested the hypothesis that apoptotic proteins are linked with K+ channel-dependent tumor cell cycle and apoptosis. The patch-clamping study using the whole-cell mode revealed two components of voltage-gated outward K… CONTINUE READING