Heat shock proteins and immunity: application of hyperthermia for immunomodulation.

  title={Heat shock proteins and immunity: application of hyperthermia for immunomodulation.},
  author={Toshihiko Torigoe and Yasuaki Tamura and Noriyuki Sato},
  journal={International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group},
  volume={25 8},
Heat shock proteins (HSPs) play an important role as 'endogenous danger signals' in the immune surveillance system. Extracellular HSPs released from damaged cells can stimulate professional antigen-presenting cells, followed by cytokine release and expression of cell surface molecules. In addition to such activity stimulating innate immunity, extracellular HSPs can promote the cross-presentation of HSP-bound peptide antigens to MHC class I molecules in dendritic cells, leading to efficient… CONTINUE READING
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