Heat-shock proteins and acute ischaemic kidney injury.

  title={Heat-shock proteins and acute ischaemic kidney injury.},
  author={Stephen O'Neill and Ewen M Harrison and James Alexander Ross and Stephen J. Wigmore and Jeremy Hughes},
  journal={Nephron. Experimental nephrology},
  volume={126 4},
The incidence of acute kidney injury due to ischaemia-reperfusion injury (IRI) is rising but effective treatments and preventative approaches are currently lacking. IRI is also an inevitable consequence of kidney transplantation and significantly contributes to delayed graft function. Heat-shock proteins (Hsps) are highly conserved and ubiquitously expressed molecular chaperones that help maintain and restore normal cellular function in the kidney following IRI. Hsp70 is one of the most… CONTINUE READING
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