Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes.

@article{Buraczynska2009HeatshockPG,
  title={Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes.},
  author={Monika Buraczynska and Andrzej Swatowski and Kinga Buraczyńska and Michal Dragan and Andrzej Książek},
  journal={Clinical science},
  year={2009},
  volume={116 1},
  pages={81-6}
}
HSPs (heat-shock proteins) are molecular chaperones synthesized under stress conditions, and are involved in renal cell survival and matrix remodelling in acute and chronic renal diseases. In the present study, we investigated whether the HSP70 gene polymorphisms affect susceptibility to DN (diabetic nephropathy) in patients with T2DM (Type 2 diabetes mellitus). The study group consisted of 452 patients with nephropathy. Two control subgroups involved 340 healthy individuals and 132 patients… CONTINUE READING

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