Heat shock protein expression and immunity: relevance to gynecologic oncology.

  • Steven S Witkin
  • Published 2001 in European journal of gynaecological oncology
Heat shock proteins function as molecular chaperones, guiding the transport, assembly and degradation of intracellular polypeptides. Under the influence of non-physiological conditions heat shock protein synthesis is accelerated to aid cell survival. Thus, over-production of heat shock proteins protects malignantly transformed cells from apoptotic cell… CONTINUE READING