Heat-shock protein-based vaccines for cancer and infectious disease

@article{Binder2008HeatshockPV,
  title={Heat-shock protein-based vaccines for cancer and infectious disease},
  author={R. Binder},
  journal={Expert Review of Vaccines},
  year={2008},
  volume={7},
  pages={383 - 393}
}
  • R. Binder
  • Published 2008
  • Biology, Medicine
  • Expert Review of Vaccines
Almost 60 years ago, the pioneering work of George Klein and others showed that cancers could be made targets for the immune system. Identification of the tumor targets, known as tumor antigens, became a focus in cancer biology that led to the discovery of the immunological properties of heat-shock proteins (HSPs) in 1986 by Pramod Srivastava and colleagues. Since then, the use of HSPs in the therapeutics of cancer and infectious disease in several clinical trials has been guided by our… Expand
CD91-Dependent Modulation of Immune Responses by Heat Shock Proteins: A Role in Autoimmunity
TLDR
The apparent dichotomy of immune responses elicited by HSPs is discussed here on a molecular and cellular level and the potential clinical application of HSP-mediated immune responses for therapy of autoimmune diseases is reviewed. Expand
Heat Shock Proteins as Immunomodulants
TLDR
The various metabolic pathways in which various Hsps manifest immune modulation are discussed, including their effects on immune cells depends on a number of aspects such as concentration of the respective Hsp species. Expand
Co-administration of GP96 and Her2/neu DNA vaccine in a Her2 breast cancer model
TLDR
The graph of tumor size demonstrated a bi-phasic pattern in which partial control of tumor progression initially occurred, but finally its effectiveness was inversely affected by tumor size. Expand
A Mage3/Heat Shock Protein70 DNA vaccine induces both innate and adaptive immune responses for the antitumor activity.
TLDR
Results indicate that the HSP-based Mage3 DNA vaccine can more effectively inhibit tumor growth by inducing both the innate immune responses and Mage3-specific adaptive immune responses via the Hsp-associated adjuvant function. Expand
The role of heat shock protein 70 (Hsp70) in radiation-induced immunomodulation.
TLDR
An irradiation-induced enhancement of the selective expression of a membrane form of Hsp70 on the surface of tumor cells which can act as a recognition structure for activated NK cells might have significant clinical relevance, in that the outcome of irradiation therapy for advanced tumors could be improved by combining it with cell-based and other immunotherapies that target this membrane form. Expand
Cutting Edge: The Heat Shock Protein gp96 Activates Inflammasome-Signaling Platforms in APCs
TLDR
The results show that murine APCs activate NLRP3 inflammasomes in response to gp96 by K+ efflux, showing a novel mechanism by which proteins of endogenous origin, the HSPs, can modulate an inflammatory response following their release from aberrant cells. Expand
Heat shock proteins 70 and 90 from Clonorchis sinensis induce Th1 response and stimulate antibody production
TLDR
This study showed for the first time that the HSP or HSP/peptide complexes of C. Sinensis could be considered as a more effective vaccine against C. sinensis infection as results of the activator of host immune response as well as the adjuvant for antigenic peptide conjugate to induce peptide-specific antibody response in mice. Expand
Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin.
TLDR
Hsp70 as a carrier protein surpassed the benchmark Her-KLH cocktail through antibody-mediated blockade of 6-acetylmorphine, the main mediator of heroin's psychoactivity and presents a new avenue for exploration in the use of hapten-Hsp 70 conjugates to elicit anti-drug immune responses. Expand
Expression of recombinant heat-shock protein 70 of MCAN/IR/96/LON-49, a tool for diagnosis and future vaccine research.
TLDR
The conservative nature of the HSP70 molecule is an advantage in vaccine studies, because of minor differences between the nucleotide sequences and consequently the similarity in amino acid sequences in various strains of L. infantum, which could be used in vaccine research against leishmaniasis and also as a tool for serodiagnosis. Expand
DNA vaccines for the treatment of prostate cancer
TLDR
This article focuses on DNA vaccines specifically in the context of prostate cancer treatment, focusing on antigens targeted in preclinical models, recent clinical trials and efforts to improve the potency of these vaccines. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 108 REFERENCES
Peptide-binding heat shock proteins in the endoplasmic reticulum: role in immune response to cancer and in antigen presentation.
TLDR
The experiments that fractionate cancer-derived proteins and test them for their ability to immunize against the cancers are discussed and the studies that suggest some radically novel opportunities for human cancer immunotherapy are discussed. Expand
Heat shock protein 70-associated peptides elicit specific cancer immunity
TLDR
The data indicate that antigenicity of hSp70 preparations derives, not from hsp70 per se, but from associated peptides, which may suggest a novel method of using the peptide-binding property of hSP70 for specific vaccination against cancer and infectious diseases. Expand
Preventive and therapeutic effect of tumor derived heat shock protein, gp96, in an experimental prostate cancer model.
TLDR
The data suggests that tumor derived gp96-peptide complexes can be used as an effective prophylactic and therapeutic agent even in poorly immunogenic cancer such as prostate cancer. Expand
Generation of heat shock protein-based vaccines by intracellular loading of gp96 with antigenic peptides.
TLDR
Testing whether an HSP-based vaccine can be preduced by overexpressing an antigen in cultured cells prior to purification of the HSP's suggests that a cellular immune response against NP was indeed induced, and SFV transfection is considered to be an elegant means for the production of H SP-based vaccines capable of inducing a Cellular immune response. Expand
Immunotherapy using heat-shock protein preparations of leukemia cells after syngeneic bone marrow transplantation in mice.
TLDR
Observations suggest that immunization of the complex of HSPs and peptides derived from leukemia cells leads to immune responses that are sufficient to reject minimal amounts of leukemia cells for relatively immunocompromised mice after syngeneic bone marrow transplantation. Expand
Immunization of cancer patients with autologous cancer‐derived heat shock protein gp96 preparations: A pilot study
TLDR
Observations in this pilot study are entirely consistent with the murine experience and form a firm basis for future trials with clinical end points, using autologous, patient‐specific HSP–peptide vaccines. Expand
Characterization of Heat Shock Protein 110 and Glucose-Regulated Protein 170 as Cancer Vaccines and the Effect of Fever-Range Hyperthermia on Vaccine Activity1
TLDR
It is shown that prior vaccination with hsp110 or grp170 purified from methylcholanthrene-induced fibrosarcoma caused complete regression of the tumor, and that fever-level hyperthermia can significantly enhance the vaccine efficiency of hsps. Expand
Tumor-specific immunogenicity of stress-induced proteins: convergence of two evolutionary pathways of antigen presentation?
TLDR
The possibility that hsps may not be antigenic per se, but may be carriers of antigenic moieties such as peptides, and may be accessory antigen-presenting molecules, is considered. Expand
Autologous tumor-derived heat-shock protein peptide complex-96 (HSPPC-96) in patients with metastatic melanoma
TLDR
Treatment with autologous tumor-derived HSPPC-96 was feasible and safe at all doses tested and the 25-μg dose level was shown to be practical for further study. Expand
Heat shock proteins transfer peptides during antigen processing and CTL priming
TLDR
It is suggested that, as with antigen presentation by MHC class II molecules, presentation by HSPs is also carried out primarily by the host antigen-presenting cells, and this mechanism explains the phenomenon of cross-priming. Expand
...
1
2
3
4
5
...