Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans.

@article{Walker2001HeatSP,
  title={Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans.},
  author={Glenda A Walker and Tiffany M. White and Geoff Mccoll and Nicole L. Jenkins and Sandra L Babich and E. Peter M. Candido and Thomas Johnson and Gordon J. Lithgow},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2001},
  volume={56 7},
  pages={B281-7}
}
We present evidence for elevated levels of heat shock protein 16 (HSP16) in an intrinsically thermotolerant, long-lived strain of Caenorhabditis elegans during and after heat stress. Mutation of the age-1 gene, encoding a phosphatidylinositol 3-kinase catalytic subunit, results in both extended life span (Age) and increased intrinsic thermotolerance (Itt) in adult hermaphrodites. We subjected age-synchronous cohorts of worms to lethal and nonlethal thermal stress and observed the accumulation… CONTINUE READING
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