Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells

Abstract

The presentation of an exogenous antigen in a major histocompatibility complex class-I- restricted fashion to CD8(+) T cells is called cross-presentation. Heat shock proteins (HSPs) such as Hsp70, gp96, and Hsp90 have been shown to elicit efficient CTL responses by cross-presentation through an as-yet entirely unknown mechanism. Hsp90 is the most abundant… (More)
DOI: 10.1111/cas.12570

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@inproceedings{Tanaka2015HeatSP, title={Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells}, author={Tsutomu Tanaka and Koichi Okuya and Goro Kutomi and Akari Takaya and Toshimitsu Kajiwara and Takayuki Kanaseki and Tomohide Tsukahara and Yoshihiko Hirohashi and Toshihiko Torigoe and Koichi Hirata and Yoshiharu Okamoto and Noriyuki Sato and Yasuaki Tamura}, booktitle={Cancer science}, year={2015} }