Heat shock protein 90 mediates cytoprotection by H₂S against chemical hypoxia-induced injury in PC12 cells.

@article{Meng2011HeatSP,
  title={Heat shock protein 90 mediates cytoprotection by H₂S against chemical hypoxia-induced injury in PC12 cells.},
  author={Jin-lan Meng and Wei-yi Mei and Yan-Fen Dong and Jian-hong Wang and Chun-mei Zhao and Ai-ping Lan and Chun-tao Yang and Pei-xi Chen and Jian-qiang Feng and Chen-Heng Hu},
  journal={Clinical and experimental pharmacology & physiology},
  year={2011},
  volume={38 1},
  pages={42-9}
}
1. Increasing evidence indicates that hydrogen sulphide (H₂S) may serve as an important biological cytoprotective agent. Heat shock protein (Hsp) 90 can attenuate stress-induced injury. However, whether Hsp90 mediates the cytoprotective effect of H₂S against chemical hypoxia-induced injury in PC12 cells is not known. 2. In the present study, CoCl₂ (a chemical hypoxia mimetic) was used to treat PC12 cells to create a model of chemical hypoxia. To explore the role of Hsp90 in the cytoprotection… CONTINUE READING