Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus.

@article{Lamoth2012HeatSP,
  title={Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus.},
  author={Fr{\'e}d{\'e}ric Lamoth and Praveen Rao Juvvadi and Jarrod R Fortwendel and William J Steinbach},
  journal={Eukaryotic cell},
  year={2012},
  volume={11 11},
  pages={1324-32}
}
Heat shock protein 90 (Hsp90) is a eukaryotic molecular chaperone. Its involvement in the resistance of Candida albicans to azole and echinocandin antifungals is well established. However, little is known about Hsp90's function in the filamentous fungal pathogen Aspergillus fumigatus. We investigated the role of Hsp90 in A. fumigatus by genetic repression and examined its cellular localization under various stress conditions. Failure to generate a deletion strain of hsp90 suggested that it is… CONTINUE READING