Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.

@article{Hughes2008HeatSP,
  title={Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.},
  author={Duncan Hughes and Joseph B Guttenplan and Craig B. Marcus and Kotha Subbaramaiah and Andrew J. Dannenberg},
  journal={Cancer prevention research},
  year={2008},
  volume={1 6},
  pages={485-93}
}
The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (HSP90), plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Tobacco smoke, a source of PAHs, activates the AhR, leading to enhanced transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. The main objectives of this study were to determine whether HSP90 inhibitors suppress PAH-mediated induction of CYP1A1 and CYP1B1 or block benzo(a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 8 Excerpts
Highly Influenced

Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2007

Effects of smoking on the pharmacokinetics of erlotinib.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2006

Similar Papers

Loading similar papers…