Heat shock protein 90 inhibitor induces apoptosis and attenuates activation of hepatic stellate cells.

@article{Myung2009HeatSP,
  title={Heat shock protein 90 inhibitor induces apoptosis and attenuates activation of hepatic stellate cells.},
  author={Sun Jung Myung and Jung-hwan Yoon and Bo Hyun Kim and Do Hyun Lee and Eun Uk Jung and Hyo-Suk Lee},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={330 1},
  pages={276-82}
}
Activated hepatic stellate cells (HSCs) are major participants in hepatic fibrosis; thus, the induction of HSC apoptosis has been proposed as an antifibrotic treatment strategy. Heat shock protein (Hsp) 90 is a molecular chaperone that stabilizes major signal transduction proteins, and its inhibitors have antitumor activity. In this study, the susceptibility of HSCs to an Hsp90 inhibitor was evaluated. LX-2 cells, an immortalized human HSC line, 17-(allylamino)-17-demethoxygeldanamycin (17AAG… CONTINUE READING

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Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling

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