Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug.

@article{Pallavi2010HeatSP,
  title={Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug.},
  author={Rani Pallavi and Nainita Roy and Rishi Kumar Nageshan and Pinaki Talukdar and Soundara Raghavan Pavithra and Raghunath Reddy and S. Venketesh and Rajender Kumar and Ashok Gupta and Raj K. Singh and Suresh Chandra Yadav and Utpal Tatu},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 49},
  pages={37964-75}
}
Using a pharmacological inhibitor of Hsp90 in cultured malarial parasite, we have previously implicated Plasmodium falciparum Hsp90 (PfHsp90) as a drug target against malaria. In this study, we have biochemically characterized PfHsp90 in terms of its ATPase activity and interaction with its inhibitor geldanamycin (GA) and evaluated its potential as a drug target in a preclinical mouse model of malaria. In addition, we have explored the potential of Hsp90 inhibitors as drugs for the treatment of… CONTINUE READING
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