Heat shock protein 70 suppresses astroglial-inducible nitric-oxide synthase expression by decreasing NFkappaB activation.

@article{Feinstein1996HeatSP,
  title={Heat shock protein 70 suppresses astroglial-inducible nitric-oxide synthase expression by decreasing NFkappaB activation.},
  author={Douglas L Feinstein and Elena Galea and Dennis A. Aquino and Gloria C. Li and Heping Xu and Donald J. Reis},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 30},
  pages={17724-32}
}
In brain glial cells, expression of calcium independent nitric-oxide synthase (NOS-2) is induced following stimulation with bacterial endotoxin (lipopolysaccharide (LPS)) and/or pro-inflammatory cytokines. We have investigated the effects of heat shock (HS), which can reduce inflammatory responses in several cell types, on the induction of glial NOS-2 expression. Preincubation of cells for 20-60 min at 43 degrees C decreased subsequent levels of NOS-2 induction, with a maximal 80% reduction… CONTINUE READING
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