Heat shock protein 70 protects PC 12 cells against ischemia-hypoxia / reoxygenation by maintaining intracellular Ca 2 + homeostasis

@inproceedings{Liu2016HeatSP,
  title={Heat shock protein 70 protects PC 12 cells against ischemia-hypoxia / reoxygenation by maintaining intracellular Ca 2 + homeostasis},
  author={Yuan Liu and Xue-chun Wang and Dan Hu and Shu-ran Huang and Qing-shu Li and Zexiang Li and Yan Qu},
  year={2016}
}
Heat shock protein 70 (HSP70) maintains Ca homeostasis in PC12 cells, which may protect against apoptosis; however, the mechanisms of neuroprotection are unclear. Therefore, in this study, we examined Ca levels in PC12 cells transfected with an exogenous lentiviral HSP70 gene expression construct, and we subsequently subjected the cells to ischemia-hypoxia/reoxygenation injury. HSP70 overexpression increased neuronal viability and ATPase activity, and it decreased cellular reactive oxygen… CONTINUE READING

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