Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation.

@article{Bhagat2000HeatSP,
  title={Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation.},
  author={Lakshmi Bhagat and Vijay P Singh and A J Hietaranta and Sudhir Agrawal and Michael L. Steer and Ashok Kumar Saluja},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={106 1},
  pages={81-9}
}
Rodents given a supramaximally stimulating dose of cholecystokinin or its analogue cerulein develop acute pancreatitis with acinar cell injury, pancreatic inflammation, and intrapancreatic digestive enzyme (i.e., trypsinogen) activation. Prior thermal stress is associated with heat shock protein 70 (HSP70) expression and protection against cerulein-induced… CONTINUE READING