Heat shock protein 70 of Naegleria fowleri is important factor for proliferation and in vitro cytotoxicity

@article{Song2008HeatSP,
  title={Heat shock protein 70 of Naegleria fowleri is important factor for proliferation and in vitro cytotoxicity},
  author={Kyoung-Ju Song and Kyung-Hui Song and Jong-Hyun Kim and Hae-Jin Sohn and Yang-Jin Lee and Chang-Eun Park and H M Shin},
  journal={Parasitology Research},
  year={2008},
  volume={103},
  pages={313-317}
}
To evaluate the role of heat shock 70 protein (HSP70) in free-living amoeba, a constitutive and inducible heat shock 70 gene of pathogenic Naegleria fowleri has previously been cloned, characterized, and named as Nf-cHSP70. The Nf-cHSP70 is localized in the cytoplasm, pseudopodia, and phagocytic food-cups. To investigate the role of Nf-cHSP70 in the pathogenicity of N. fowleri, the synthesis of N. fowleri HSP70 was first inhibited with benzylidene lactam compound (KNK437), and Nf-cHSP70 gene… CONTINUE READING

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