Heat shock protein 70 moderately enhances peptide binding and transport by the transporter associated with antigen processing.

@article{Chen2001HeatSP,
  title={Heat shock protein 70 moderately enhances peptide binding and transport by the transporter associated with antigen processing.},
  author={Dung-Tsa Chen and Matthew J. Androlewicz},
  journal={Immunology letters},
  year={2001},
  volume={75 2},
  pages={143-8}
}
Hsp70 molecules are capable of binding antigenic peptides and eliciting CTL responses to the bound peptide. However, the precise mechanism for the induction of CTL has not been determined. One possibility is that hsp molecules can directly shuttle peptides in the MHC class I antigen processing and presentation pathway, as previously postulated. Here, we have addressed this issue by testing the effect of purified hsp70 molecules on peptide binding and transport by the transporter associated with… CONTINUE READING

From This Paper

Topics from this paper.
17 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…