Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein

@inproceedings{Piao2009HeatSP,
  title={Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein},
  author={Longzhen Piao and Yuwen Li and Keum-Jin Yang and Kyeong Ah Park and Hee Sun Byun and Minho Won and Jang Hee Hong and Jeong-Lan Kim and Gi Ryang Kweon and Gang Min Hur and Jeong Ho Seok and Jae Youl Cho and Taehoon Chun and Daniel Hess and Ragna Sack and S Maira and Derek P. Brazil and Brian A. Hemmings and Jongsun Park},
  booktitle={BMC Cell Biology},
  year={2009}
}
The serine/threonine protein kinase B (PKB/Akt) is involved in insulin signaling, cellular survival, and transformation. Carboxyl-terminal modulator protein (CTMP) has been identified as a novel PKB binding partner in a yeast two-hybrid screen, and appears to be a negative PKB regulator with tumor suppressor-like properties. In the present study we investigate novel mechanisms by which CTMP plays a role in apoptosis process. CTMP is localized to mitochondria. Furthermore, CTMP becomes… CONTINUE READING
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