Heat-shock protein 70 mRNA is induced by anaerobic metabolism in rat hearts.

@article{Myrmel1994HeatshockP7,
  title={Heat-shock protein 70 mRNA is induced by anaerobic metabolism in rat hearts.},
  author={Truls Myrmel and James D McCully and L Malikin and Irvin B. Krukenkamp and Sidney Levitsky},
  journal={Circulation},
  year={1994},
  volume={90 5 Pt 2},
  pages={II299-305}
}
BACKGROUND Both heat-shock protein (HSP) 70 and its mRNA are induced in the ischemic myocardium. The inductor stimuli are, however, not known. Stretch and ischemic metabolic alterations are the two most likely HSP70 inductors. METHODS AND RESULTS To assess whether anaerobic metabolism induces HSP70 mRNA expression, 61 rat hearts were perfused with Krebs-Henseleit buffer (37 degrees C) in a modified Langendorff apparatus built for rapid switching between pressure-controlled and flow-controlled… CONTINUE READING
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