Heat shock protein 70 is secreted from tumor cells by a nonclassical pathway involving lysosomal endosomes.

@article{Mambula2006HeatSP,
  title={Heat shock protein 70 is secreted from tumor cells by a nonclassical pathway involving lysosomal endosomes.},
  author={Salamatu S. Mambula and Stuart K. Calderwood},
  journal={Journal of immunology},
  year={2006},
  volume={177 11},
  pages={7849-57}
}
Heat shock protein (HSP)70 can be released from tumor cells and stimulate a potent antitumor immune response. However, HSP70 does not contain a consensus secretory signal and thus cannot traverse the plasma membrane by conventional mechanisms. We have observed HSP70 release from intact human prostate carcinoma cell lines (PC-3 and LNCaP) by a mechanism independent of de novo HSP70 synthesis or cell death. This pathway is similar to one used by the leaderless protein IL-1beta. Our studies show… CONTINUE READING
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