Heat shock protein 27 regulates neutrophil chemotaxis and exocytosis through two independent mechanisms.

@article{Jog2007HeatSP,
  title={Heat shock protein 27 regulates neutrophil chemotaxis and exocytosis through two independent mechanisms.},
  author={Neelakshi R. Jog and Venkatakrishna R Jala and Richard A. Ward and Madhavi J. Rane and Bodduluri Haribabu and Kenneth R Mcleish},
  journal={Journal of immunology},
  year={2007},
  volume={178 4},
  pages={2421-8}
}
The targets of the p38 MAPK pathway responsible for regulation of neutrophil chemotaxis and exocytosis are unknown. One target of this pathway is the actin-binding protein, heat shock protein 27 (Hsp27). Therefore, we tested the hypothesis that Hsp27 mediates p38 MAPK-dependent chemotaxis and exocytosis in human neutrophils through regulation of actin reorganization. Sequestration of Hsp27 by introduction of anti-Hsp27 Ab, but not an isotype Ab, inhibited fMLP-stimulated chemotaxis, increased… CONTINUE READING
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