Heat shock protein 27 protects against atherogenesis via an estrogen-dependent mechanism: role of selective estrogen receptor beta modulation.

@article{Rayner2009HeatSP,
  title={Heat shock protein 27 protects against atherogenesis via an estrogen-dependent mechanism: role of selective estrogen receptor beta modulation.},
  author={Katey J. Rayner and Jiangfeng Sun and Yong-Xiang Chen and Melissa S McNulty and Trevor Simard and Xiaoling Zhao and Dominic J Wells and Jacqueline de Belleroche and Edward R O'brien},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2009},
  volume={29 11},
  pages={1751-6}
}
OBJECTIVE We recently identified HSP27 as an atheroprotective protein that acts extracellularly to prevent foam cell formation and atherogenesis in female but not male mice, where serum levels of HSP27 were increased and inversely correlated with degree of lesion burden. In the current study we sought to determine whether estrogens are required for the observed atheroprotective benefits of HSP27 as well as its extracellular release. METHODS AND RESULTS In vitro estrogens prompted the release… CONTINUE READING
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Selective activation of estrogen receptor beta attenuates atherogenesis and represses cholesterolassociated immune-inflammatory responses. Circulation

  • J Sun, X Ma, +7 authors ER. O’Brien
  • 2008

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