Heat-shock protein 27 (Hsp27) as a target of methylglyoxal in gastrointestinal cancer.


The molecular mechanisms underlying the posttranslational modification of proteins in gastrointestinal cancer are still unknown. Here, we investigated the role of methylglyoxal modifications in gastrointestinal tumors. Methylglyoxal is a reactive dicarbonyl compound produced from cellular glycolytic intermediates that reacts non-enzymatically with proteins… (More)
DOI: 10.1016/j.bbadis.2011.03.017

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