Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish.

@article{Feng2007HeatshockIO,
  title={Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish.},
  author={Hui Feng and David M Langenau and Jennifer A Madge and Andr{\'e} Quinkertz and Alejandro Gutierrez and Donna S Neuberg and John P. Kanki and A Thomas Look},
  journal={British journal of haematology},
  year={2007},
  volume={138 2},
  pages={169-75}
}
The zebrafish is an ideal vertebrate model system to investigate the complex genetic basis of cancer because it has the capacity for in vivo tumour-cell imaging and forward genetic screens, and the molecular mechanisms regulating malignancy are remarkably conserved when compared with human. Our laboratory has previously generated transgenic zebrafish models that overexpress the mouse c-Myc gene fused to enhanced green fluorescent protein (EGFP) and develop T-cell acute lymphoblastic leukaemia… CONTINUE READING
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