Heat shock gene expression in Xenopus laevis A6 cells in response to heat shock and sodium arsenite treatments.

@article{Darasch1988HeatSG,
  title={Heat shock gene expression in Xenopus laevis A6 cells in response to heat shock and sodium arsenite treatments.},
  author={S P Darasch and Dick D. Mosser and Niels Christian Bols and John J. Heikkila},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={1988},
  volume={66 8},
  pages={
          862-70
        }
}
Continuous exposure of a Xenopus laevis kidney epithelial cell line, A6, to either heat shock (33 degrees C) or sodium arsenite (50 microM) resulted in transient but markedly different temporal patterns of heat-shock protein (HSP) synthesis and HSP 70 and 30 mRNA accumulation. Heat-shock-induced synthesis of HSPs was detectable within 1 h and reached maximum levels by 2-3 h. While sodium arsenite induced the synthesis of some HSPs within 1 h, maximal HSP synthesis did not occur until 12 h. The… CONTINUE READING
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