Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells.

  title={Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells.},
  author={Sabrina Fritah and Edwige Col and Cyril Boyault and J{\'e}r{\^o}me Govin and Karin Sadoul and Susanna Chiocca and Elisabeth Christians and Saadi Khochbin and Caroline Jolly and Claire Vourc'h},
  journal={Molecular biology of the cell},
  volume={20 23},
A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation. Investigating the underlying mechanisms, we show that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock-dependent histone deacetylation. This work… CONTINUE READING
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