Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase

@article{Gauhar2012HeatprocessedGP,
  title={Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase},
  author={Rehman Gauhar and Seung-Lark Hwang and Si-Sung Jeong and Ji-Eun Kim and Hebok Song and Dong Chan Park and Kyung-sik Song and Tae Young Kim and Won Keun Oh and Tae-lin Huh},
  journal={Biotechnology Letters},
  year={2012},
  volume={34},
  pages={1607-1616}
}
Gynostemma pentaphyllum is widely used in Asian countries as a herbal medicine to treat dyslipidemia, type 2 diabetes and inflammation. An ethanol extract of G. pentaphyllum lessened obesity by activating AMP-activated protein kinase (AMPK). The levels of damulins A and B, components responsible for AMPK activation in the extract, were increased by autoclaving in a time-dependent manner. Heat-processed G. pentaphyllum extract, actiponin containing damulins A (0.93 %, w/w) and B (0.68 %, w/w… CONTINUE READING

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