Heat loss reaction to capsaicin through a peripheral site of action

@article{Donnerer1983HeatLR,
  title={Heat loss reaction to capsaicin through a peripheral site of action},
  author={Josef Donnerer and Fred Lembeck},
  journal={British Journal of Pharmacology},
  year={1983},
  volume={79}
}
1 The intravenous injection of 15 fig capsaicin produced an increase in the temperature of tail skin and paw pad and a fall in the colon temperature in conscious rats. These reactions reflect increased heat dissipation. 2 The increase in skin temperature induced by intravenous capsaicin was absent when the function of small diameter primary afferent neurones was impaired by treatment of the rats with capsaicin as neonates. Thus it appears that intravenous capsaicin triggered the… 
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42 Citations

Reflex control of the cutaneous circulation after acute and chronic local capsaicin.

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Effects of intrathecal capsaicin on autonomic and behavioral heat loss responses in the rat

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Capsaicin-induced reflex fall in rat blood pressure is mediated by afferent substance P-containing neurones via a reflex centre in the brain stem

Using spinal rats or decerebration experiments, the centre of the capsaicin-evoked reflex fall in blood pressure could be localized in the brain stem and was exclusively mediated by substance P-containing primary afferent fibres.

Participation of capsaicin-sensitive afferent neurons in gastric motor inhibition caused by laparotomy and intraperitoneal acid

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At 30°C CA, thermal responses were accompanied by arterial hypotension most likely due to the interactive effects of both stressors (warm environment and capsaicin) on cutaneous vascular regulation.

Thermoregulatory behaviour induced by intrathecal injection of substance P in the rat.

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Thermoregulatory and cardiovasculareffects of capsaicin application on human skin during dynamic exercise to temperate and warm conditions

Thermoregulatory and cardiovascular responses during cycling in temperate and warm environments without and with application of capsaicin on the skin were investigated. We hypothesized that…

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It is shown that intragastric administration of 10 and 15 mg/kg capsaicin increased tail temperature and decreased colonic temperatures in the core temperature (CT)-constant and CT-decreasing conditions and that preliminary thermoregulation state might be more important than the constancy of temperature to evaluate the effects of heat diffusion and thermogensis.

Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons.

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