Heat-killed Lactobacillus casei confers broad protection against influenza A virus primary infection and develops heterosubtypic immunity against future secondary infection

@article{Jung2017HeatkilledLC,
  title={Heat-killed Lactobacillus casei confers broad protection against influenza A virus primary infection and develops heterosubtypic immunity against future secondary infection},
  author={Yu-Jin Jung and Young‐Tae Lee and Vu L Ngo and Young-Hee Cho and Eun-Ju Ko and Sung-Moon Hong and Ki-hye Kim and Ji-Hun Jang and Joon-Suk Oh and Min-Kyung Park and Cheol-Hyun Kim and Jun Sun and Sang-Moo Kang},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
Lactic acid bacteria (LAB) are the common probiotics. Here, we investigated the antiviral protective effects of heat-killed LAB strain Lactobacillus casei DK128 (DK128) on influenza viruses. Intranasal treatment of mice with DK128 conferred protection against different subtypes of influenza viruses by lessening weight loss and lowering viral loads. Protection via heat-killed DK128 was correlated with an increase in alveolar macrophage cells in the lungs and airways, early induction of virus… 
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