Heat induction of the unphosphorylated form of hypoxia-inducible factor-1alpha is dependent on heat shock protein-90 activity.

@article{Katschinski2002HeatIO,
  title={Heat induction of the unphosphorylated form of hypoxia-inducible factor-1alpha is dependent on heat shock protein-90 activity.},
  author={Dorthe M Katschinski and Lu Q. Le and Daniel Heinrich and Klaus F. Wagner and Thomas Hofer and Susann Gaby Schindler and Roland H. Wenger},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 11},
  pages={9262-7}
}
Hypoxia-inducible factor (HIF)-1alpha is the oxygen-sensitive subunit of HIF-1, a transcriptional master regulator of oxygen homeostasis. Oxygen-dependent prolyl hydroxylation targets HIF-1alpha for ubiquitinylation and proteasomal degradation. Unexpectedly, we found that exposing mice to elevated temperatures resulted in a strong HIF-1alpha induction in kidney, liver, and spleen. To elucidate the molecular mechanisms responsible for this effect, HepG2 hepatoma cells were exposed to different… CONTINUE READING

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Heat-induced HIF-1α protein stabilization

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