Heat-induced changes in intracellular sodium and membrane potential: lack of a role in cell killing and thermotolerance.

@article{Amorino1996HeatinducedCI,
  title={Heat-induced changes in intracellular sodium and membrane potential: lack of a role in cell killing and thermotolerance.},
  author={George P. Amorino and Michael H Fox},
  journal={Radiation research},
  year={1996},
  volume={146 3},
  pages={283-92}
}
Hyperthermia induces transient changes in intracellular free sodium levels and membrane potential. The possible role of these changes in cell killing by hyperthermia and thermotolerance has been evaluated using Chinese hamster ovary IS1 and HeLa cells. Intracellular sodium was measured with Sodium Green and SBFI, while membrane potential was measured with the oxonol dye diBAC4(3). Heating at either 42.0 or 45.0 degrees C caused nearly the same decrease in free [Na+]i from about 20 mM in… CONTINUE READING
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