Heat exposure of Cannabis sativa extracts affects the pharmacokinetic and metabolic profile in healthy male subjects.

@article{Eichler2012HeatEO,
  title={Heat exposure of Cannabis sativa extracts affects the pharmacokinetic and metabolic profile in healthy male subjects.},
  author={Martin Eichler and Luca Spinedi and Sandra Unfer-Grauwiler and Michael Bodmer and Christian Surber and Markus M Luedi and Juergen Drewe},
  journal={Planta medica},
  year={2012},
  volume={78 7},
  pages={686-91}
}
The most important psychoactive constituent of CANNABIS SATIVA L. is Δ (9)-tetrahydrocannabinol (THC). Cannabidiol (CBD), another important constituent, is able to modulate the distinct unwanted psychotropic effect of THC. In natural plant extracts of C. SATIVA, large amounts of THC and CBD appear in the form of THCA-A (THC-acid-A) and CBDA (cannabidiolic acid), which can be transformed to THC and CBD by heating. Previous reports of medicinal use of cannabis or cannabis preparations with higher… CONTINUE READING
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RF.Unheated Cannabis sativa extracts and its major compound THC-acid have potential immunomodulating properties not mediated by CB1 and CB2 receptor coupled pathways

  • KC Verhoeckx, HA Korthout, +5 authors Witkamp
  • Int Immunopharmacol
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Unheated Cannabis sativa extracts and its major compound THCacid have potential immunomodulating properties not mediated by CB 1 and CB 2 receptor coupled pathways

  • KC Verhoeckx, HA Korthout, +5 authors RF Witkamp
  • Int Immunopharmacol
  • 2006

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