Heat exposure enhances radiosensitivity by depressing DNA-PK kinase activity during double strand break repair.

@article{Ihara2014HeatEE,
  title={Heat exposure enhances radiosensitivity by depressing DNA-PK kinase activity during double strand break repair.},
  author={Makoto Ihara and Satoshi Takeshita and Kumio Okaichi and Yutaka Okumura and Takeo Ohnishi},
  journal={International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group},
  year={2014},
  volume={30 2},
  pages={102-9}
}
PURPOSE From the role of double strand DNA dependent protein kinase (DNA-PKcs) activity of non-homologous end joining (NHEJ) repair for DNA double strand breaks (DSBs), we aim to define possible associations between thermo-sensitisation and the enzyme activities in X-ray irradiated cells. MATERIALS AND METHODS DNA-PKcs deficient mouse, Chinese hamster and human cultured cells were compared to the parental wild-type cells. The radiosensitivities, the number of DSBs and DNA-PKcs activities… CONTINUE READING

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