Heat capacity changes upon burial of polar and nonpolar groups in proteins.

@article{Loladze2001HeatCC,
  title={Heat capacity changes upon burial of polar and nonpolar groups in proteins.},
  author={Vakhtang V Loladze and Dmitri N. Ermolenko and George I. Makhatadze},
  journal={Protein science : a publication of the Protein Society},
  year={2001},
  volume={10 7},
  pages={
          1343-52
        }
}
In this paper we address the question of whether the burial of polar and nonpolar groups in the protein locale is indeed accompanied by the heat capacity changes, DeltaC(p), that have an opposite sign, negative for nonpolar groups and positive for polar groups. To accomplish this, we introduced amino acid substitutions at four fully buried positions of the ubiquitin molecule (Val5, Val17, Leu67, and Gln41). We substituted Val at positions 5 and 17 and Leu at position 67 with a polar residue… CONTINUE READING

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