Heat-activated liposomal MR contrast agent: initial in vivo results in rabbit liver and kidney.

@article{McDannold2004HeatactivatedLM,
  title={Heat-activated liposomal MR contrast agent: initial in vivo results in rabbit liver and kidney.},
  author={Nathan J. McDannold and Sigrid L Fossheim and Henrik Rasmussen and Heather B Martin and Natalia Vykhodtseva and Kullervo Hynynen},
  journal={Radiology},
  year={2004},
  volume={230 3},
  pages={743-52}
}
PURPOSE To evaluate by using in vivo magnetic resonance (MR) imaging the functionality of a liposomal paramagnetic contrast agent with T1 relaxivity that rapidly and markedly increases at temperatures above the gel-to-liquid crystalline phase transition temperature (T(c)) of the liposome membrane. MATERIALS AND METHODS Liposomal gadolinium diethylenetriaminepentaacetic acid bis(methylamide) was injected intravenously at a dose of 0.4 or 1.2 mL (containing 10 or 30 micromol of gadolinium… CONTINUE READING