Heat Shock Protein 47: A Novel Biomarker of Phenotypically Altered Collagen-Producing Cells

@inproceedings{Taguchi2011HeatSP,
  title={Heat Shock Protein 47: A Novel Biomarker of Phenotypically Altered Collagen-Producing Cells},
  author={Takashi Taguchi and Arifa Nazneen and Abdulmonem A. Al-Shihri and Khadijah A. Turkistani and Mohammed Shawkat Razzaque},
  booktitle={Acta histochemica et cytochemica},
  year={2011}
}
Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that helps the molecular maturation of various types of collagens. A close association between increased expression of HSP47 and the excessive accumulation of collagens is found in various human and experimental fibrotic diseases. Increased levels of HSP47 in fibrotic diseases are thought to assist in the increased assembly of procollagen, and thereby contribute to the excessive deposition of collagens in fibrotic areas… CONTINUE READING