Heat Shock Protein 27 Protects Against Atherogenesis via an Estrogen-Dependent Mechanism: Role of Selective Estrogen Receptor Beta Modulation

@article{Rayner2009HeatSP,
  title={Heat Shock Protein 27 Protects Against Atherogenesis via an Estrogen-Dependent Mechanism: Role of Selective Estrogen Receptor Beta Modulation},
  author={K. Rayner and Jiangfeng Sun and Y. Chen and M. McNulty and T. Simard and X. Zhao and D. Wells and J. De Belleroche and E. O’Brien},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
  year={2009},
  volume={29},
  pages={1751-1756}
}
  • K. Rayner, Jiangfeng Sun, +6 authors E. O’Brien
  • Published 2009
  • Biology, Medicine
  • Arteriosclerosis, Thrombosis, and Vascular Biology
  • Objective—We recently identified HSP27 as an atheroprotective protein that acts extracellularly to prevent foam cell formation and atherogenesis in female but not male mice, where serum levels of HSP27 were increased and inversely correlated with degree of lesion burden. In the current study we sought to determine whether estrogens are required for the observed atheroprotective benefits of HSP27 as well as its extracellular release. Methods and Results—In vitro estrogens prompted the release of… CONTINUE READING
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