Heat Shock Partially Dissociates the Overlapping Modules of the Yeast Protein-Protein Interaction Network: A Systems Level Model of Adaptation

@inproceedings{Mihalik2011HeatSP,
  title={Heat Shock Partially Dissociates the Overlapping Modules of the Yeast Protein-Protein Interaction Network: A Systems Level Model of Adaptation},
  author={{\'A}goston Mihalik and P{\'e}ter Csermely},
  booktitle={PLoS Computational Biology},
  year={2011}
}
Network analysis became a powerful tool giving new insights to the understanding of cellular behavior. Heat shock, the archetype of stress responses, is a well-characterized and simple model of cellular dynamics. S. cerevisiae is an appropriate model organism, since both its protein-protein interaction network (interactome) and stress response at the gene expression level have been well characterized. However, the analysis of the reorganization of the yeast interactome during stress has not… CONTINUE READING
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The BioGRID interaction database: 2011 update

  • C Stark, BJ Breitkreutz, A Chatr-Aryamontri, L Boucher, R Oughtred
  • Nucleic Acids Res
  • 2011
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