Heat-Modified Citrus Pectin Induces Apoptosis-Like Cell Death and Autophagy in HepG2 and A549 Cancer Cells

@inproceedings{Leclere2015HeatModifiedCP,
  title={Heat-Modified Citrus Pectin Induces Apoptosis-Like Cell Death and Autophagy in HepG2 and A549 Cancer Cells},
  author={Lionel Leclere and Maude Fransolet and François X C{\^o}te and Pierre Cambier and Thierry Arnould and Pierre Van Cutsem and Carine Michiels},
  booktitle={PloS one},
  year={2015}
}
Cancer is still one of the leading causes of death worldwide, and finding new treatments remains a major challenge. Previous studies showed that modified forms of pectin, a complex polysaccharide present in the primary plant cell wall, possess anticancer properties. Nevertheless, the mechanism of action of modified pectin and the pathways involved are unclear. Here, we show that citrus pectin modified by heat treatment induced cell death in HepG2 and A549 cells. The induced cell death differs… CONTINUE READING
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