Hearts of some Antarctic fishes lack mitochondrial creatine kinase.

@article{OBrien2014HeartsOS,
  title={Hearts of some Antarctic fishes lack mitochondrial creatine kinase.},
  author={Kristin M O'Brien and Irina A Mueller and Julieanna I Orczewska and Kristin Dullen and M Ortego},
  journal={Comparative biochemistry and physiology. Part A, Molecular & integrative physiology},
  year={2014},
  volume={178},
  pages={30-6}
}
Creatine kinase (CK; EC 2.7.3.2) functions as a spatial and temporal energy buffer, dampening fluctuations in ATP levels as ATP supply and demand change. There are four CK isoforms in mammals, two cytosolic isoforms (muscle [M-CK] and brain [B-CK]), and two mitochondrial isoforms (ubiquitous [uMtCK] and sarcomeric [sMtCK]). Mammalian oxidative muscle couples expression of sMtCK with M-CK, creating an energy shuttle between mitochondria and myofibrils. We hypothesized that the expression pattern… CONTINUE READING

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