Heart-stopping antibodies

  title={Heart-stopping antibodies},
  author={Heather L. Van Epps},
  journal={The Journal of Experimental Medicine},
  pages={2 - 2}
Spred-1 moderates eosinophil activation normally mediated by IL-5, according to a study by Inoue et al. on page 73. Mice lacking Spred-1 have overly exuberant eosinophils and develop exaggerated allergic responses to inhaled antigens. Allergies and asthma are characterized by invasion of the airways by T cells and eosinophils. A subset of CD4 T cells, known as Th2 cells, produce an array of cytokines, including IL-5 and IL-13, which recruit eosinophils to the lung where they release their… CONTINUE READING