Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos.

@article{Zhao2008HeartspecificIO,
  title={Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos.},
  author={Long Zhao and Xinyi Zhao and Tian Tian and Quanlong Lu and Nirma Skrbo-Larssen and Di Wu and Zheng Kuang and Xiaofeng Zheng and Yanchao Han and Shuyan Yang and Chuanmao Zhang and Anming Meng},
  journal={Cardiovascular research},
  year={2008},
  volume={80 2},
  pages={
          200-8
        }
}
AIMS Tropomyosin (Tpm) proteins, encoded by four Tpm genes (Tpm1-4), are associated with the stabilization of the F-actin filaments and play important roles in modulating muscle contraction. So far, little is known about Tpm4 function in embryonic heart development and its involvement in the cardiovascular diseases. In this study, we investigated functions of different isoforms of tpm4 in embryonic heartbeat in zebrafish. METHODS AND RESULTS The transgenic zebrafish line, T2EGEZ8, was… CONTINUE READING
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