Heart-specific Rpd3 downregulation enhances cardiac function and longevity

  title={Heart-specific Rpd3 downregulation enhances cardiac function and longevity},
  author={Zachary A. Kopp and Jo-Lin Hsieh and Andrew C. Li and William G. J. Wang and Dhelni T. Bhatt and Angela M Lee and Sae Yeon Kim and David Sicong Fan and Veevek Shah and Emaad Siddiqui and Radhika Ragam and Kristen Park and Dev Ardeshna and Kunwoo Park and R. T. Wu and Hardik A Parikh and Ayush Parikh and Y Lin and Yongkyu Park},
Downregulation of Rpd3, a homologue of mammalian Histone Deacetylase 1 (HDAC1), extends lifespan in Drosophila melanogaster. Once revealed that long-lived fruit flies exhibit limited cardiac decline, we investigated whether Rpd3 downregulation would improve stress resistance and/or lifespan when targeted in the heart. Contested against three different stressors (oxidation, starvation and heat), heart-specific Rpd3 downregulation significantly enhanced stress resistance in flies. However, these… CONTINUE READING
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